Queen's University

An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products

Johnston CW, Skinnider MA, Wyatt MA, Li X, Ranieri MRM, Yang L, Zechel DL, Bin Ma, and Magarvey NA*. An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products. Nature Comms 2015, 6, 1–11.

An innovative combination of bioinformatics, chemoinformatics, and LC-MS/MS that allows one to predict the structures of bacterial natural products based on genetic information and then look for the corresponding molecules in culture extracts. Our favourite bacterium Streptomyces calvus figures prominently in this paper where we use this method to identify a non-ribosomal peptide encoded by an unusual NRPS gene cluster.