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Contribution of the early immune response to inflammatory pain

The inflammatory response to tissue injury, such as after post-surgical wounds, results in the rapid recruitment of neutrophils, monocytes/macrophages, and T cells to the affected site. Cell depletion strategies have identified a subset of monocytes that are responsible for chronic mechanical hypersensitivity. However, there are several immune cell types including mast cells, dendritic cells, and γ/δ T cells that are activated in seconds-to-minutes after injury, before the infiltration of other cells. How these early-response immune cells affect acute and chronic pain outcomes remains largely unknown. We will therefore use human and animal tissues from various injury models to assess the activation state of these cells over time and, using knockout/cell-depletion strategies, their contribution to acute and chronic pain outcomes.

Thermal and mechanical hypersensitivity after peripheral inflammation in C57BL/6J mice.